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Phase I metabolism of dihexa, which was determined using pooled male rat liver microsomes, was found to be very low, with an average intrinsic clearance (Cl int ) of 2.72 l/min/mg and an average half-life of 509.4 minutes
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Hyperandrogenism is associated with earlier age of onset of idiopathic intracranial hypertension in women
8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years
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