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[DOI] [PubMed] [Google Scholar] 70.Tosukhowong P., Boonla C., Dissayabutra T., Kaewwilai L., Muensri S., Chotipanich C., Joutsa J., Rinne J., Bhidayasiri R
When this occurs, additional free radicals are produced which, in turn, can result in more extensive damage to cells and tissues
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By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)