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These interactions may reduce the efficacy of drugs like oral contraceptives and alter the absorption of medications such as digoxin and statins, necessitating careful monitoring and adjustments

Permanent effects are rare and usually linked to misuse or unregulated products

This is exactly why controlled trials are needed and why microdosing should be approached with appropriate medical supervision, not self-experimented with based on internet articles alone

doi: 10.1159/000530456 105 HuszarDLynchCAFairchild-HuntressVDunmoreJHFangQBerkemeierLR

Thorwarth M, Schultze-Mosgau S, Wehrhan F, Kessler P, Srour S, Wiltfang J, et al

353 However, the number of compounds that target the p53 Y220C mutant is limited