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In SLE, B cells contribute to pathogenesis through to the generation of autoantibodies

Access this article Similar content being viewed by others Abbreviations GSH: l--glutamyl-l-cysteinyl-glycine (glutathione) GSSG: Oxidised form of glutathione DEM: Diethylmaleate H 2 S: Hydrogen sulfide IL-6: Interleukin-6 JNK: c-Jun- N -terminal kinase MAPK: Mitogen-activated protein kinase NF-B: Nuclear factorB SAPK: Stress-activated protein kinase TNF: Tumour necrosis factor xCT: Subunit of the x c cystine-glutamate exchanger References Aitken SM, Kirsch JF (2005) The enzymology of cystathionine biosynthesis: strategies for the control of substrate and reaction specificity

Therefore, strategies that modulate immune infiltration and function must balance the suppression of pathological inflammation with the preservation of protective immune mechanisms

Future studies with larger samples may help delineate the significance of TRX-1 measurement in BPD or ROP and improve our understanding of this important molecule from a development point of view

CrossRef Endocrine alterations from concentric vs

Cytosolic cystine is further reduced by consuming NADPH to cysteine as a starting material for GSH synthesis [79]