G6PD-deficient cells are unable to generate enough NADPH under the condition of severe thiol depletion and GSH biosynthesis and methionine cycle are upregulated at the expense of ATP but fail to compensate for GSH depletion (311)
And without those bonds, it wont be absorbed into our systems
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J Membr Biol 69:112 Mulcahy RT, Bailey HH, Gipp JJ (1995) Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan
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