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There is also emerging research suggesting tirzepatide may have a favourable effect on body composition, meaning a meaningful proportion of the weight lost tends to come from fat mass rather than lean muscle, particularly when treatment is paired with adequate protein intake and resistance exercise

Cryan JF, Dinan TG

(PubMed) Wolffenbuttel BH, Owen PJ, Ward M, Green R

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This connection is distinctly intertwined with obesity, a canonical precursor to various metabolic disorders, including T2DM, hypertension, and hyperlipidemia