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Safety really comes down to proper dosing and patient selection by a licensed provider. A 2025 review that assessed the safety profiles of both drugs found that the most common adverse effects are the same for both tirzepatide and semaglutide, namely, nausea, vomiting and diarrhea

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These medications have seen an explosion in sales with the approval and off-label use for weight loss, typically resulting in a reduction in body weight of 15-21% when combined with nutrition and exercise