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High levels of homocysteine, with the slowing of GPx1 blood vessel activity, promote a higher concentration of intracellular peroxides that enhances oxidative stress and causes damage to endothelial cells in the pathogenesis of atherogenesis

Common Lifestyle Habits That Deplete Glutathione Smoking: Tobacco smoke is a major source of oxidative stress

The administration of the gamma subtype of peroxisome proliferator-activated receptors (PPAR) ligands has been demonstrated to reduce the production of inflammatory cytokines, such as IL-1 and TNF-, as well as inhibit the proliferation of inflammatory cells and the expression of specific adhesion molecules (305)