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They are grounded in endogenous biology, often supported by convergent evidence across species and experimental modalities, and frequently act at integrative nodes that coordinate multiple physiological processes

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Clinical studies show that patients typically lose 10-20% of their body weight over several months with GLP-1 therapy

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The higher the CD177 pos /mPR3 high neutrophil percentage, the stronger the PR3-ANCAinduced neutrophil activation in vitro (149) and the worse the clinical outcome (150, 151)

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