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However, a study published in the Journal of the International Society of Sports Nutrition concluded that you do not have to load creatine

Once produced and used, it is broken down by an enzyme called gamma-glutamyl transferase, GGT

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However, there are situations where the needs increase or the intake decreases : intense exercise, aging or diets with little animal protein (like vegetarian or vegan) are the most common

This tripeptide is made up of cysteine, glutamic acid and glycine