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At Lady Reading Hospital (LRH), Peshawar (Khyber Pakhtunkhwa Province), efficacy of Sucrosomial B12 was compared with conventional formulated B-SUB B12 (Methylcobalamin 1,000 g, manufactured by Bio Life Enterprises Nutraceuticals and marketed by Honing Pharmaceutical Laboratories, Rawalpindi, Pakistan)

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193 It is important to note that some evidence indicates repeated high doses of cyanocobalamin may be harmful in those with kidney disease

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Pooled effect analysis indicated a significant higher protein level in CRC patients (WMD (95% CIs) = 11.24 (4.18, 18.30), p = 0.002)

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