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2,3 The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb.) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb.) for the placebo group which was statistically significant

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In addition, microglia can respond to neurotransmitters such as dopamine and norepinephrine, influencing their activation state and subsequent inflammatory response [126,127]

Thus, long-term supplementation of an aging population with adequate doses of melatonin may help to improve the health status of the targeted group of elderly people