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These approaches aim to reprogram TAMs from a pro-tumorigenic M2 state to an anti-tumorigenic M1 phenotype, thereby enhancing immune responses and overcoming resistance to treatments such as chemotherapy and immune checkpoint inhibitors

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10.1016/bs.mie.2014.11.005 27 StepanenkoA

Anti-Inflammatory Effects Persistent inflammation slows recovery

Together, GABA signaling is highly disturbed in PD and associated with developing motor and non-motor symptoms (van Nuland et al