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Skin sensitization data from patch testing in cosmetic research applications showed no significant contact sensitization at concentrations typical to topical research use (PMID: 23024678)

For example, Souza et al (2007) showed that a highly palatable diet (enriched with sucrose) increases protein oxidation in the frontal cortex and appeared to induce anxiety-like behavior in rats [66]

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If an individual did switch medications, this was noted and the reasons for switching were recorded

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