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doi: 10.1056/NEJMoa1912196 95 van VollenhovenRAskanaseADBombackASBruceINCarrollADallEraMet al

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Dig Dis Sci (2002) 47(6):140512

While brain interstitial fluid tau concentrations are reported to be nearly twice as high during the active period of the rest-activity cycle in humans [8], it is noteworthy that, to the best of our knowledge, no study has investigated whether the deletion of core clock genes, simulating circadian disruption, leads to an increase in tau hyperphosphorylation

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