Some studies suggest that introducing healthy mitochondria into cancer cells can enhance their sensitivity to ferroptosis inducers [174], while other studies indicate that mitochondrial fusion may activate protective metabolic axes (e.g., Nrf2), thereby promoting tumor growth [175]
CYP enzymes are a superfamily of hemoproteins that carry out oxidative metabolism of many endogenous and foreign chemicals
Glutathione, the cell's primary antioxidant, neutralizes reactive oxygen species and supports Phase II detoxification pathways
The CD68 +Ve immune reaction was measured within 10 non-overlapping fields/sections for each animal
10.1038/nature07813 8 de GregorioE.ColellA.MoralesA.MarM
Free Radic Biol Med 122: 116- 129 Terai Y, Ueno H, Ogawa T, Sawa Y, Miyagi A, Kawai-Yamada M, Ishikawa T, Maruta T (2020) Dehydroascorbate reductases and glutathione set a threshold for high light-induced ascorbate accumulation