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4.4.5 Increasing Insulin Production: GLP1 Agonists Similar to the mechanism with DDP-4 inhibitors, GLP1 agonists involve directly injecting the incretin GLP1 (comparable to injecting the hormone insulin in Type 1 Diabetes)

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Under conditions of compromised mitochondrial function, the PMF falls below the threshold required for ATP synthesis and the activity of ATP synthase can actually reverse such that it hydrolyzes ATP to pump protons back into the inner membrane space