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Multiple Sclerosis and Related Disorders, 27 , 52-60

Reduced glutathione (GSH) occurs naturally in all human cells

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Neuroimmune communication via calcitonin gene-related peptide (CGRP) and its coreceptor RAMP1 promotes macrophage recruitment and phenotypic shifts toward a pro-endometriosis state, characterized by impaired efferocytosis and enhanced support of endometrial cell growth ( Natural killer (NK) cell function is severely compromised, with reduced cytotoxicity of the CD56dimCD16+ subset in peripheral blood and peritoneal fluid, enabling immune escape of ectopic cells ( T-cell subsets are dysregulated, with increased Th2, Th17, and regulatory T (Treg) cells in the peritoneal microenvironment ( 2.2.2 Immune checkpoint molecules Immune checkpoint pathways are perturbed, contributing to immunosuppression