Yes, based on available evidence, concurrent use appears safe since semaglutide and glutathione operate through different biological pathways
In a letter (PDF) to shareholders, executives said the company has a legal pathway to sell "personalized titration schedules and dosage levels that are not essentially copies of commercially available medications" that allow providers to "meet the needs of individual patients regardless of shortage dynamics." Hims & Hers said revenue from its non-GLP-1 offerings totaled $1.2 billion of the $1.48 billion that it brought in last year, suggesting the company sold roughly $200 million in compounded GLP-1 drugs last year
Combined with exercise and a low-calorie diet, the Wegovy pill is intended for use in people with overweight, obesity, or weight-related medical problems, as well as to reduce the risk of major adverse cardiovascular events such as death, heart attack, or stroke in adults with overweight or obesity and heart disease
Berberine also induces apoptosis via the mitochondrial pathway, promoting the release of cytochrome c from mitochondria, activating caspase-8, 9, and subsequent caspase-3 cascades, and triggering apoptosis by inhibiting the expression of Bcl-2 while increasing pro-apoptotic proteins (85)
Although NO production was enhanced considerably in Long COVID, nitrotyrosine levels were not altered, although increased nitrotyrosine indicates an increase in reactive nitrogen species with increased NO2 binding to tyrosine, thereby forming an immunogenic neoepitope [89]
However, their effects are not uniformly beneficial
