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Despite the substantial improvements in body weight and glucose control elicited by GLP-1R agonists, patient uptake and compliance are challenged by frequent gastrointestinal adverse events (GI AEs), including nausea and vomiting, that necessitate careful dose titration regimens to achieve efficacious exposure (14)

In tumor cells, this AMPK-mediated mTOR inhibition limits proliferation by restricting energy and biosynthetic precursors (65)

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Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, Khoury JE, Golenbock DT, Moore KJ

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