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OA-VI12 was shown to promote the expression of miR-122-5p while downregulating the expression of MITF and TYR, suggesting that it inhibited melanin synthesis through the miR-122-5p/MITF/TYR axis

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For other experiments (for example, experiments using in vitro-cultured ovaries), the principles are the same as mentioned earlier

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Julius M., Lang C.A., Gleiberman L., Harburg E., Difranceisco W., Schork A