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These systems improve pharmacological performance and align polyphenol-based strategies more closely with synthetic small-molecule and biologic therapies

The gut also clearly contributes immune cells to pathological conditions that modulate neuroinflammation, as demonstrated by the migration of gut-derived IgA + plasma cells into the CNS during EAE and the infiltration of intestinal T cells and monocytes into the CNS in a mouse model of stroke [258, 259]

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The extract demonstrated a favorable safety profile, characterized by the absence of significant adverse events or laboratory abnormalities