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512 Deficits of astrocytic support of synaptogenesis can also be linked to a decrease in secretion of astrocyte-specific synaptogenic molecules such as hevin, SPARC proteins and thrombospondin-1

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A multicenter prospective cohort study that followed 319 patients with SCAs (15 years) found no difference in the rate of disease progression over two years between those taking supplemental coenzyme Q 10 (median dose, 600 mg/day) and nonusers (81)