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Most patients notice visible improvements within 6-8 weeks, though individual results may vary

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Broyer M, Tete MJ, Guest G, Bertheleme JP, Labrousse F, Poisson M (1996) Clinical polymorphism of cystinosis encephalopathy

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Remarkably, the heterologous expression of an engineered bifunctional bacterial GSH biosynthetic enzyme ( GshF ) in mitochondria enabled mitochondrial GSH production and ameliorated the metabolic and proliferative defects caused by its depletion