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Causes include poor dietary intake, blood loss (e.g., heavy menstruation or gastrointestinal bleeding), or conditions that reduce iron absorption, such as coeliac disease or Crohns disease

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It is indicated in patients with nonfunctional pituitary adenomas or other nonlactotroph adenomas associated with hyperprolactinemia and in patients in whom medical therapy has been unsuccessful or poorly tolerated

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In such a case, damage to the brain may occur which may accelerate the epilepsy process