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We now recognize that many gout patients with elevated 24-hour urine uric acid have renal uric overload due to intestinal ABCG2 dysfunction, without uric acid overproduction

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Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) showing promising early evidence for significant weight reduction, improved metabolic markers, and reduced liver fat, but it has not yet received MHRA or EMA approval

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