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Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy

They provide minimal nutrition relative to calories

Pipeline Portfolio 8.1.2

doi: 10.1109/JSTQE.2016.2561201 25 YamadaEFBobinskiFMartinsDFPalandiJFolmerVda SilvaMD

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however, no significant reduction was observed dulaglutide [MD = 0.08, 95% CI (7.8, 9.4), p = 0.86]