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While the short-term benefits may seem appealing, the long-term risks are too significant to ignoreespecially when safer, better-understood alternatives are available

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[DOI] [PMC free article] [PubMed] [Google Scholar] [12].Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG, Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

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