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Although it is not yet clear whether micronutrient supplementation has beneficial effects on various cognitive domains, it is well established that micronutrient deficiencies, especially B vitamin deficiencies, have adverse effects on cognition

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Preclinical studies in in vitro models have shown that simvastatin exerted its anti-tubercular activity through cholesterol-driven autophagy, which is mediated by the adenosine monophosphate-activated protein kinase (AMPK)mammalian target of the rapamycin complex 1 (mTORC1)TFEB axis [58] (Fig