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UV Protection: The colorless carotenoids (phytoene and phytofluene) in white tomato extract offer both internal and topical photoprotection by absorbing UVA and UVB rays

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Before advancing these strategies to clinical application, several key challenges must be addressed, such as the complexity and functional redundancy of the ferroptosis regulatory network, the limitations of existing animal models in simulating the pathological features of human chronic OA, and the lack of reliable biomarkers for assessing intra-articular ferroptosis activity in humans