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Because of the severity of the interaction, in published drug databases (i.e UpToDate LexiDrug, Clinical Pharmacology, etc.), the interaction is listed as a Avoid Combination (X) and/or Level 1 (Contraindicated). For this reason, many patients and practitioners avoid the use of methylene blue 9-26

95% CI, 0.03 to 1.17

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They temporarily improve it, but without SCFAs, microbial repair, and control of inflammation , insulin resistance often returns

When it comes to GLP-1 side effects, gastrointestinal issues tend to steal the spotlight