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Proglucagon, a precursor polypeptide, undergoes tissue-specific post-translational processing to yield various biologically active peptides in the pancreas and the gut/brain

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This strategy aims to maintain more consistent blood levels and reduce peak-related side effects

This work was conducted in accordance with the international standards of animal protection and the ethical principles of the National Council of Animal Experimentation and was approved by the Ethics Committee on Animal Use of the University Federal of Ouro Preto (#2014/17)