Further analysis showed aberrant expression of iron autophagy-related genes, such as elevated expression of ATG5, nuclear receptor coactivator 4 (NCOA4), and ferritin heavy chain 1 (FTH1), and decreased expression of glutathione peroxidase 4 (GPX4) and tumor suppressor protein p53 (TP53, Fig
11 Some of these targets are shown in Table 1
This bifocal regulatory mechanism extends to the gut, where polyphenols promote the growth of A
doi:10.3892/etm.2020.9260 119 Sharafkhah, M., Abdolrazaghnejad, A., Zarinfar, N., Mohammadbeigi, A., Massoudifar, A
The role appears to be partially mediated through the recruitment of fibroblasts
Originally characterized at the University of Florida by the Stephen ORahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints