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However, further dedicated clinical studies are needed to evaluate the efficacy and safety of these treatments in kidney fibrosis

These mechanisms still need to be further studied

Krknen et al., 2017

Thus, they are supported by stringent Federal Drug Administration (FDA) guidelines ensuring their efficacy and safety [87]

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Both clinical trials and observational studies have shown that intentional weight loss, whether through lifestyle change, bariatric surgery, or pharmacotherapy, is associated with reduced disease activity, improved joint symptoms, and enhanced response to biologics (31, 32)