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Keywords: fibrosis, GLP1, incretin, MASH, MASLD Abbreviations ACC acetylCoA carboxylase ALT alanine aminotransferases AMPK AMPactivated protein kinase ChREBP carbohydrateresponse elementbinding protein ECM extracellular matrix ELF enhanced liver fibrosis panel FAS fatty acid synthase FAST FibroscanAST score GLP1 glucagon like peptide1 GLP1R glucagonlike peptide1 receptor GLP1RA glucagon like peptide1 receptor agonist HMGCR 3hydroxy3methylglutarylCoA reductase HSC hepatic stellate cells IL6 interleukin6 LSM liver stiffness measurement LTA4 leukotriene A4 MACE major adverse cardiovascular events MASH metabolic dysfunctionassociated steatohepatitis MASLD metabolic dysfunctionassociated steatotic liver disease MCP1 monocyte chemoattractant protein1 SCD1 stearoylCoA desaturase1 SREBP1c sterol regulatory elementbinding protein 1c T2D type 2 diabetes TNF tumour necrosis factor VCTE vibrationcontrolled transient elastography SMA smooth muscle actin Summary

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P., et al., Efruxifermin in Compensated Liver Cirrhosis Caused by MASH, New England Journal of Medicine 392, no

With 100 mg and 300 mg of canagliflozin, incidence rates were reported as 0.52 and 0.76 per 1000 patient/yr respectively