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Development of patient-derived gastric cancer organoids from endoscopic biopsies and surgical tissues

Upon binding, the receptor-ligand complex initiates intracellular signaling cascades involving pathways such as phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), as well as mitogen-activated protein kinase (MAPK) signaling

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Advances in Gerontology, 2024

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The same disparity between rich animal data and sparse human trials characterizes many peptide compounds, partly because the economics of pharmaceutical development disfavor compounds that cannot be patented in their natural form