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doi:10.1016/j.ajcnut.2025.04.023 2 DiNicolantonio JJ, Berger A

Speak to a doctor about dose changes if needed Some people may benefit from dose adjustments if they have not yet reached their planned maintenance dose

Pharmacological GLP-1RA Action Key Mechanistic Distinctions A comprehensive review published in Cell Metabolism reviewed circuits engaged by endogenous versus pharmacological GLP-1 action, highlighting key GLP-1R-positive cell types and pathways transducing metabolic and non-glycaemic GLP-1 signals

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101 Additionally, the ongoing CAROLINA study (Cardiovascular Outcome Study of Linagliptin Against Glimepiride in Type 2 Diabetes Patients) is investigating the cardiovascular outcomes of linagliptin

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