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Regulatory-T-cell instability also arises through epigenetic mechanisms: Patients with RA exhibit reduced FOXP3 expression and insufficient demethylation of the FOXP3 TSDR, while MTX therapy can restore Treg function by demethylating a FOXP3 enhancer, associating pharmacologic intervention to methylome repair (123,124)

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EVs may carry lipids or other nutrients to the embryo, supporting embryo elongation