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10.1016/j.ymthe.2025.04.026 279 ZhongY.HuangT.HuangJ.QuanJ.SuG.XiongZ.et al (2023)

When melatonin levels fall, oxidative stress rises accelerating neuronal ageing and the build-up of damaging amyloid and tau proteins (1, 2)

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This could also help account for why Tesofensine is not reliably self-administered by human stimulant abusers [15] since it has been believed to be the case that DAT inhibition is necessary for this and not NET inhibition

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