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[DOI] [PubMed] [Google Scholar] 3.Sikiric P., Hahm K.B., Blagaic A.B., Tvrdeic A., Pavlov K.H., Petrovic A., Kokot A., Gojkovic S., Krezic I., Drmic D., et al

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Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient