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however, this has not been confirmed in peer-reviewed literature and the evidence is very limited it should not be assumed to be a drug effect without further data Rapid weight loss a well-documented effect of retatrutide may also contribute indirectly to skin changes

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Therapies that can break this cycle could significantly improve patient outcomes

Skin experiences the highest load of oxidative stress when compared to all other organs in the body

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Overall the absolute risk was around 40% when a GLP1-RA was specifically used to lose weight compared to around 27% when the drug was used for type II diabetes