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Multiple clinical trials in photoaged skin (sun damage) have shown that topical GHK-Cu formulations improve skin appearance including reductions in fine lines and wrinkles, improvement in skin firmness and elasticity, enhancement of skin texture and smoothness, increase in skin thickness (reversing age-related dermal atrophy), improvement in skin clarity and reduction in hyperpigmentation, and overall rejuvenated appearance

Mitochondrial GSH sequesters copper, preventing its binding to lipoylated proteins, such as DLAT, thereby blocking the aberrant protein oligomerization that drives this cell death pathway [109]

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