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In Rheumatoid Arthritis, the immune system creates a storm of oxidative stress and cytokines (like TNF- and IL-6)

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15,16 Jennings et al 15 demonstrated a significant decrease in weight (6.5 kg), HS Physicians Global Assessment (HS-PGA) (from 4 to 1), DLQI (from 24 to 14), and analgesic use (from daily to not daily) but no decrease in CRP (from 3 mg/dL) after eight weeks of treatment