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6 Conclusion Experimental evidence suggests that SGLT2 inhibitors may inhibit ferroptosis through the regulation of iron balance, lipid metabolism, and antioxidant systems

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Reduced ubiquinone and vitamin E levels, and reduced activity of the enzyme glutathione peroxidase in lymphocytes and granulocytes were reported (with a decrease in 51 and 78%, respectively), as well as a decrease in glutathione reductase activity in granulocytes (27%) and lymphocytes (8%) [13]