For individuals on cyclosporine or levothyroxine, it is important to time these medications to avoid interference with orlistat
Better convenience: Weekly dosing is easier for the vast majority of patients
Lameris AL, Nevalainen PI, Reijnen D, et al
Your own exposure & equity curve will give you less of a comprehensive read into how the thematic trend is performing and you may lose out in the long term from benefits that are secondary and tertiary to the thematic rather than just primary
Full disclosure I've also become more active and have been trying to maintain 10000 steps a day in addition to the GLP1 pills
A 2012 study found that older adults (65+ years) supplementing L-carnitine during resistance training and caloric deficits lost significantly more fat while preserving more lean mass compared to controls, suggesting that carnitine becomes a legitimate intervention in aging populations (Kraemer et al., 2006)