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Optional 4 week break after week 12, then resume at maintenance dosing

Discuss your health: Talk about medications and supplements youre taking, side effects that youre worried about, mental health concerns, and family history, especially medullary thyroid cancer

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The abnormal extracellular matrix and tumor vasculature surrounding tumor cells result in uneven drug distribution within the tumor, thereby reducing the effective drug concentration ( CAFs play a critical role in tumor progression and drug resistance by secreting growth factors and cytokines that promote tumor cell proliferation and migration

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