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DALYs and mortality related to obesity are the consequence of the multiple comorbidities spanning from cardiovascular (CV) and metabolic diseases, such as heart failure (HF) and type 2 diabetes (T2D), to many cancers, infertility and respiratory (e.g., obstructive apnea syndrome), cutaneous (e.g

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Nevertheless, in the absence of family studies or multiple occurrences of a new genetic variant in unrelated families, the majority of the gene variants remain of unknown significance (VUS) or have an area of doubt and therefore their interpretation and clinical use pose a problem