is oprah on semaglutide Winfrey's Weight Loss: Everything She's Said About Her Health and GLP-1s Oprah's Wellness Path: Semaglutide's Role

Prior to naltrexone initiation: Ask about opioid use history or if currently on buprenorphine or methadone Administer a 0.4 mg IV naloxone challenge dose Will help to determine if naltrexone would precipitate withdrawal If no precipitated withdrawal occurs, proceed with treatment Start naltrexone treatment: Oral: Start with 50 mg PO naltrexone Injectable: Start with 380 mg IM naltrexone Discharge planning: If PO naltrexone is given, then discharge the patient with a prescription for up to 30 days (50 mg daily)

Yi, M., Chen, D., Tang, Y., Tang, L., & Zhai, D

Eur Heart J (2020) 41(48):456576

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Importantly, Table 3 presents a summary of important GLP-1 trials that focus on aging-related outcomes

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