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GLP-1 receptor agonists and renal outcomes Based on the US FDA industry guidance issued in 2008, all new glucose-lowering agents were required to perform a large-sized placebo-controlled cardiovascular outcome/safety trial, usually conducted in people with T2D with pre-existent or at high-risk of developing CVD

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Semaglutide is built around GLP-1 activity, Tirzepatide combines GIP and GLP-1 pathways, while Retatrutide is being studied across GIP, GLP-1, and glucagon receptors

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Porcu M, Urbano MR, Verri WA Jr, Barbosa DS, Baracat M, Vargas HO, et al