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Additionally, studies have indicated that in hypoxia-activated BV2 microglia and hypoxic neonatal rats, Dex could reduce synaptic loss and neuronal damage in the hippocampus, and the underlying mechanism may be attributed to its ability to prevent hypoxia-induced activation of nicotinamide adenine dinucleotide phosphate oxidases (NOX2) in microglia, thereby inhibiting oxidative stress and neuroinflammatory responses [55]

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All these companies are facing the same reason for not obtaining approval. According to Novo Nordisks 2025 annual report, the patent protection periods for all three semaglutide products Wegovy Ozempic and Rybelsus indeed expire in China in 2026

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Analytical capability for GLP-1 molecules has advanced substantially in parallel with synthesis technology